An association of BMI with A (-6) G, M235T and T174M polymorphisms in angiotensinogen gene in essential hypertension
نویسندگان
چکیده
منابع مشابه
Angiotensinogen M235T and T174M gene polymorphisms in combination doubles the risk of mortality in heart failure.
Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. In this study, heart failure patients (n=451) were genotyped for the angiotensinogen M235T and T174M polymorphisms to investigate association with survival (recorded over 4 years of follow-up) and prognostic hormone marke...
متن کاملAssociation of angiotensinogen M235T and A(-6)G gene polymorphisms with coronary heart disease with independence of essential hypertension: the PROCAGENE study. Prospective Cardiac Gene.
OBJECTIVES We examined the relationship between the angiotensinogen (AGT) gene M235T polymorphism, the variant promoter of the AGT gene A(-6)G and the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and coronary heart disease (CHD) in native Gran Canaria Island habitants, who have the highest rates of CHD in Spain. BACKGROUND Some studies subject that the ACE (I...
متن کاملMeta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?
Angiotensinogen (AGT) gene polymorphisms have been linked to increased risk of hypertension, but the data remain controversial. In this study we review the most commonly investigated polymorphisms at the AGT locus (other than M235T) and provide summary estimates regarding their association with essential hypertension, while addressing heterogeneity, as well as publication biases. Data on 26 818...
متن کاملAssociation of T174M polymorphism of angiotensinogen gene with essential hypertension: A meta-analysis
The association between T174M polymorphism of angiotensinogen gene and essential hypertension risk remains controversial. We herein performed a meta-analysis to achieve a reliable estimation of their relationship. All the studies published up to May 2013 on the association between T174M polymorphism and essential hypertension risk were identified by searching the electronic repositories PubMed,...
متن کاملAngiotensinogen gene polymorphisms M235T/T174M: no excess transmission to hypertensive Chinese.
The gene encoding angiotensinogen (AGT) has been widely studied as a candidate gene for hypertension. Most studies to date have relied on case-control analysis to test for an excess of AGT variants among hypertensive cases compared with normotensive controls. However, with this design, nothing guarantees that a positive finding is due to actual allelic association as opposed to an inappropriate...
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ژورنال
عنوان ژورنال: Journal of Human Hypertension
سال: 2002
ISSN: 0950-9240,1476-5527
DOI: 10.1038/sj.jhh.1001409